Now SAM-E 400MG – 30 E-COATED TABS

$84.99

FORMAT

Tabs

30 E-coated Tabs

DOSAGE

As a dietary supplement, take 1 tablet daily, preferably on an empty stomach. Refrigeration recommended after opening.

IMPORTANT INFORMATION

Contains no: sugar, salt, starch, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives. Vegetarian/Vegan Product. See warnings below.

1 in stock (can be backordered)

EAN: 733739801395 Category:

Description

NERVOUS SYSTEM SUPPORT & OSTEOARTHRITIS

SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate minor joint discomfort resulting from overexertion or stress. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation. [TABLETS]

1 Tablet Contains:
400mg
SAMe (S-Adenosyl-L-Methionine)
(from 800 mg of S-Adenosyl-L-Methionine Disulfate Tosylate)
Other Ingredients:
Cellulose, Croscarmellose Sodium Methacrylic Acid, Magnesium Stearate (vegetable source), Silica, Triethyl Citrate,Stearic Acid (vegetable source), Citric Acid and Ascorbic Acid.

Highlights
  • Nervous System Support
  • Supports Emotional Well-Being
  • Supports Joint Health*
  • Vegetarian Formula
  • Enteric Coated
  • What is SAMe?
    SAMe (S-adenosylmethionine or S-Adenosyl-L-Methionine) is a naturally occurring compound found in all human tissue and organs. It is a building block necessary for the production of many compounds produced by your body, and is used in over 35 different biochemical reactions. SAMe actually donates a part of itself to form these new compounds through a process called methylation, or transmethylation. SAMe is one of the few dietary supplements on the market today that combines the benefits of several nutrients into one, because the body uses the substances produced from SAMe for numerous body processes, including detoxification.Are there any side effects associated with SAMe supplementation?
    SAMe is a very safe dietary supplement. Minor side effects include nausea and gastrointestinal irritation, probably due to its sulfur content. But these were only noted at very high doses (1200-1600mg), and the symptoms diminished with continued use. Persons suffering from manic depression (bipolar disorder) should not take SAMe without prior consultation with their physician. If you experience any of these symptoms, it may not be the right supplement for you. The mineral Sulfur is not related to sulfa drugs or allergies related to sulfa drugs.Why is the dosage information with SAMe supplements so confusing?
    SAMe in its pure form as found in human cells has a very short life span and is rapidly metabolized into other necessary compounds as needed, which is good! However, this natural form does not allow for the production of a stable, effective dietary supplement. It took scientists years to come up with a way to stabilize SAMe so it could be manufactured as a dietary supplement. It was finally discovered that SAMe (S-Adenosyl-L-Methionine) must be manufactured in a stable salt form (for example, as S-Adenosyl-L-Methionine Disulfate Tosylate) to prevent rapid degradation. In this form, you will actually get 200mg of SAMe compounded in a stable form. However, only half of this 200mg is pure SAMe (S-Adenosyl-L-Methionine). Please note that this salt is not a significant source of sodium.

    Are there size or color variations with your SAMe products, and should SAMe be refrigerated?
    Because of the nature of SAMe, NOW takes special precautions when packaging this product. Extensive stability testing was performed in order to create this uniquely stabilized product. We bottle SAMe in amber glass bottles to keep light exposure to a minimum, and keep SAMe products refrigerated in our plant until shipping. It is not necessary to keep SAMe refrigerated after purchase, but it will extend the shelf life of the product. The bottle should be kept closed between uses, away from excessive heat and moisture.

    Because SAMe is a natural product, there can be variations in color, usually ranging from white to pale yellow or tan. This is normal and does not affect the quality of the product. You may also notice a difference in tablet size between different potencies. SAMe is available in 100mg, 200mg, and 400mg enteric-coated tablets, all coming in different sizes.

    SAMe – Amino Acids to Support Positive Mental Function

    As the building blocks of proteinAmino Acids are vital to health. Next to water, amino acids in the form of proteins make up the greatest portion of our body weight. They comprise tendons, muscles and ligaments; organs and glands; hair and nails; important bodily fluids, and are a necessary part of every cell in the body.

    There are over 20 amino acids, separated into two categories essential and non-essential. Essential amino acids are those that cannot be manufactured by your body, hence, it is essential that you obtain them from your diet. Non-essential amino acids can be manufactured by your body, however, your body must have the right combination of essential amino acids and supporting nutrients to optimize healthy protein maintenance, so supplementation may be desirable.

    Amino acids are not only absolutely integral to life, but they can have a profound impact upon how clearly we think and how well we feel.

    SAMe (S-adenosylmethionine) is a naturally occurring combination of the amino acid methionine and ATP (adenosine triphosphate), the body’s primary energy molecule. In this form it is sometimes referred to as “active methionine”. Research indicates that SAMe plays a vital role in nervous system health and normal cognitive function.

    SAMe may support nervous system function by increasing the synthesis and recycling of certain neurotransmitters and enhancing the sensitivity of nerve receptors. SAMe is believed to positively effect a number of neurotransmitters, including serotonin, dopamine, noradrenaline and norepinephrine. Although the mechanism for SAMe’s impact upon neural function is not fully understood, there is no doubt that SAMe’s capacity as a methyl donor is of critical importance.

    As a methyl donor SAMe assists the body in the creation of complex organic compounds necessary for normal healthy function. Your body uses these new compounds for numerous purposes, including brain function and detoxification. This process, known as methylation or transmethylation, is vital to your body’s maintenance. SAMe may be the most effective of all methyl donors discovered to date. Research has shown that SAMe is the only methyl donor with the potential to increase transmethylation in the brain, which helps to protect it from homocysteine damage as well as increasing production of glutathione, one of the body’s most effective antioxidants.

    Research into the biosynthesis of SAMe has established a clear link between SAMe and folic acid, or folate. Folic Acid has been proven to provide support for healthy nervous system function and a healthy mood, and researchers believe these two nutrients work together to beneficially effect monoamine systems, which directly affect mood and cognitive function. SAMe has also been show to improve the synthesis of phospholipids for use in the brain, probably one of the most beneficial effects SAMe has on brain health.

    The benefits of SAMe extend beyond the brain and throughout the human body. For example, it may also aid in the repair of myelin, the sheath of fatty material that surrounds nerves and nerve cells everywhere in our nervous system. SAMe is found in all human tissue and organs and is available for use by your body in over 35 different biochemical reactions necessary for optimal health.

    SAMe may support joint health through transulfuration, a process that takes a certain amount of sulfur from SAMe to create glucosamine and chondroitin sulfates. This enhances proteoglycan synthesis, the molecule responsible for keeping articular (joint) cartilage lubricated. As mentioned earlier, SAMe is also important for the production of glutathione, a powerful free radical scavenger that defends your body from toxic agents and is necessary for liver detoxification.*

    SAMe was first isolated in 1952 by G.L. Cantoni at the Laboratory of Cellular Pharmacology at the National Institutes of Health, Bethesda, Maryland. Four years later, Cantoni and a co-worker found that SAMe synthesis involves methionine and ATP. They also found that it exists in the human body only temporarily, making production in a supplemental form difficult. It took nearly ten years until improvements in technology permitted SAMe research to advance. With the discovery of a method to stabilize SAMe that overcame these manufacturing problems, U.S. patents were granted to allow the production of SAMe in a stabilized form.

    SAMe in its ion form as found in human cells has a very short life span and is rapidly metabolized into other necessary compounds as needed. Therefore, it must be manufactured in a stabilized form to prevent rapid degradation as a supplement. Once tableted, it must be enteric coated to preserve stability. This technology was not readily available until the 1990’s, hence SAMe’s long road to mainstream popularity. Dr. Joseph Zhou, Director of Laboratory Methods here at NOW, is credited with significantly improving the analytical methodology used to assure potency levels in supplemental SAMe. His work is one of the reasons SAMe is available as a supplement with stable, guaranteed potency.

    Warning: Individuals with bipolar (manic) depression should not take SAMe unless under professional medical supervision.84.99

Additional information

Weight 65 g


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